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Phospho-PPP1R12A/PPP1R12B/PPP1R12C (Thr696) Antibody (PA5-121344) in WB
Western blot analysis of Phospho-PPP1R12A/PPP1R12B/PPP1R12C (Thr696) in extracts of Jurkat cells. Samples were incubated with Phospho-PPP1R12A/PPP1R12B/PPP1R12C (Thr696) Polyclonal antibody (Product # PA5-121344) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. Jurkat cells were treated by Calyculin A (100 nM) at 37°C for 30 minutes after ... View More
产品信息
PA5-121344
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic phosphorylated peptide around T696 of human PPP1R12A/PPP1R12B/PPP1R12CPPP1R12A (NP_0024711)
偶联物
形式
Liquid
浓度
0.36 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914916
产品详细信息
Positive test controls include: Jurkat.
Immunogen sequence: RSTQG
靶标信息
Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. [NCBI]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: leukocyte receptor cluster (LRC) encoded novel gene 3; leukocyte receptor cluster (LRC) member 3; myosin binding subunit; Myosin phosphatase target subunit 1; Myosin phosphatase target subunit 2; myosin phosphatase, target subunit 1; myosin phosphatase, target subunit 2; Myosin phosphatase-targeting subunit 1; Myosin phosphatase-targeting subunit 2; myosin-binding subunit 85; PPP1R12C; Protein phosphatase 1 myosin-binding subunit of 85 kDa; Protein phosphatase 1 myosin-binding subunit p85; Protein phosphatase 1 regulatory subunit 12A; Protein phosphatase 1 regulatory subunit 12B; Protein phosphatase 1 regulatory subunit 12C; protein phosphatase 1, regulatory (inhibitor) subunit 12A; protein phosphatase 1, regulatory (inhibitor) subunit 12B; protein phosphatase 1, regulatory (inhibitor) subunit 12C; protein phosphatase 1, regulatory subunit 12A; protein phosphatase 1, regulatory subunit 12B; protein phosphatase 1, regulatory subunit 12C; Protein phosphatase myosin-binding subunit
基因别名: LENG3; M130; MBS; MBS85; MYPT1; MYPT2; p84; p85; PP1bp55; PPP1R12A; PPP1R12B; PPP1R12C
UniProt ID: (Human) O14974, (Human) O60237, (Human) Q9BZL4
Entrez Gene ID: (Human) 4659, (Human) 4660, (Human) 54776
G2/M transition of mitotic cell cycle
protein dephosphorylation
mitotic nuclear division
signal transduction
regulation of cell adhesion
regulation of myosin-light-chain-phosphatase activity
positive regulation of myosin-light-chain-phosphatase activity
cellular response to drug
negative regulation of catalytic activity
positive regulation of transcription from RNA polymerase II promoter
regulation of nucleocytoplasmic transport
centrosome organization
regulation of establishment of endothelial barrier
regulation of muscle contraction
positive regulation of catalytic activity
