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7TM Antibodies
Phospho-Proteinase-Activated Receptor 2 (Ser383, Ser384) Polyclonal Antibody
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Phospho-Proteinase-Activated Receptor 2 (Ser383, Ser384) Antibody (7TM0348B) in WB
Agonist-induced Serine383/Serine384 phosphorylation of the Proteinase-Activated Receptor 2. Upper panel, HEK293 cells stably expressing the Proteinase-activated Receptor 2 (PAR2) were either not exposed or exposed to 100 nM AC264613 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS383/pS384-PAR2 antibody (7TM0348B) at a dilution of 1:1,000. Lower panel, blot was stripped and reprobed with ... View More
产品信息
7TM0348B
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic phosphopeptide derived from human PAR2 around the phosphorylation site of Ser383/Ser384.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
Dulbecco's PBS, pH 7.4
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice (domestic); Dry ice (international)
靶标信息
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: coagulation factor II (thrombin) receptor-like 1; Coagulation factor II receptor-like 1; G-protein coupled receptor 11; PAR-2; protease-activated receptor 2; Proteinase-activated receptor 2; Thrombin receptor-like 1
基因别名: F2RL1; GPR11; PAR2
UniProt ID: (Human) P55085
Entrez Gene ID: (Human) 2150
T cell activation involved in immune response
positive regulation of leukocyte chemotaxis
positive regulation of cytokine secretion involved in immune response
positive regulation of glomerular filtration
inflammatory response
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
blood coagulation
negative regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of phosphatidylinositol 3-kinase signaling
regulation of blood coagulation
positive regulation of cell migration
positive regulation of actin filament depolymerization
positive regulation of pseudopodium assembly
positive regulation of superoxide anion generation
positive regulation of toll-like receptor 2 signaling pathway
negative regulation of toll-like receptor 3 signaling pathway
positive regulation of toll-like receptor 3 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
positive regulation of Rho protein signal transduction
chemokine (C-C motif) ligand 2 secretion
neutrophil activation
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of eosinophil degranulation
innate immune response
positive regulation of vasodilation
positive regulation of transcription from RNA polymerase II promoter
regulation of JNK cascade
negative regulation of JNK cascade
positive regulation of JNK cascade
interleukin-1 beta secretion
leukocyte migration
positive regulation of chemotaxis
positive regulation of positive chemotaxis
defense response to virus
positive regulation of phagocytosis, engulfment
establishment of endothelial barrier
positive regulation of ERK1 and ERK2 cascade
thrombin receptor signaling pathway
leukocyte proliferation
positive regulation of neutrophil mediated killing of gram-negative bacterium
interleukin-10 secretion
interferon-gamma secretion
chemokine secretion
negative regulation of chemokine secretion
mature conventional dendritic cell differentiation
positive regulation of renin secretion into blood stream
positive regulation of interleukin-8 secretion
positive regulation of interleukin-6 secretion
