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Phospho-ROS1 (Tyr2274) Antibody (PA5-105915) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-ROS1 (Tyr2274) in human lung cancer tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-ROS1 (Tyr2274) polyclonal antibody (Product # PA5-105915) using a dilution of 1:200 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-105915
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ROS1(Accession P08922), corresponding to amino acid residues around phosphorylated Tyr2274.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2817314
产品详细信息
Antibody detects endogenous levels of ROS only when phosphorylated at Tyr2274.
靶标信息
ROS1 is a tyrosine kinase that functions as a growth or differentiation factor receptor. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: c-ros oncogene 1 , receptor tyrosine kinase; c-Ros receptor tyrosine kinase; c-ros-1; heart - derived c - ros - 1 proto - oncogene; Proto-oncogene c-Ros; Proto-oncogene c-Ros-1; Proto-oncogene tyrosine-protein kinase ROS; Receptor tyrosine kinase c-ros oncogene 1; ROS proto-oncogene 1 , receptor tyrosine kinase; Ros1 proto-oncogene; RP1-179P9.1; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homolog 1
基因别名: c-ros; c-ros-1; MCF3; ROS; Ros-1; ROS1; ROS1C
UniProt ID: (Human) P08922, (Rat) Q63132, (Mouse) Q78DX7
Entrez Gene ID: (Human) 6098, (Rat) 25346, (Mouse) 19886
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding
protein phosphatase binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
columnar/cuboidal epithelial cell development
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
spermatogenesis
cell proliferation
negative regulation of gene expression
regulation of phosphate transport
cell growth
signal transduction by protein phosphorylation
cell differentiation
regulation of TOR signaling
peptidyl-tyrosine autophosphorylation
regulation of ERK1 and ERK2 cascade
peptidyl-tyrosine phosphorylation
phosphorylation
