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Invitrogen
Phospho-Rb (Ser788) Recombinant Rabbit Monoclonal Antibody (6H13L22)
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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Phospho-Rb (Ser788) Antibody (702111) in ICC/IF
For immunofluorescence analysis, COLO 205 cells were fixed and permeabilized for detection of endogenous RbpS788 using Anti-RbpS788 Recombinant Rabbit Monoclonal Antibody (Product # 702111, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Nuclei (blue) were stained using SlowFade® Gold Antifade Mountant with ... View More
产品信息
702111
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
6H13L22
抗原
Peptide corresponding to Human RB1 (aa 784-791)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2632993
产品详细信息
This antibody is predicted to react with Monkey, Rabbit, Bovine and Pig
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cleaved Rb; delta RB-p70; DRb-p70; exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; p105-Rb; P105RB; p110-RB1; Phospho-Retinoblastoma; pp110; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; Rb; Rb-p70; Retin; Retinoblastoma; retinoblastoma 1; retinoblastoma gene; retinoblastoma suspectibility protein; Retinoblastoma-associated protein
基因别名: OSRC; p105-Rb; pp110; PPP1R130; pRb; RB; RB1
UniProt ID: (Human) P06400
Entrez Gene ID: (Human) 5925
core promoter binding
RNA polymerase II activating transcription factor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
transcription factor binding
kinase binding
ubiquitin protein ligase binding
identical protein binding
androgen receptor binding
phosphoprotein binding
chromatin/chromatin-binding, or -regulatory protein
cell cycle checkpoint
G1/S transition of mitotic cell cycle
regulation of transcription involved in G1/S transition of mitotic cell cycle
chromatin remodeling
transcription, DNA-templated
negative regulation of protein kinase activity
cell cycle arrest
negative regulation of transcription from RNA polymerase II promoter during mitosis
mitotic cell cycle checkpoint
Ras protein signal transduction
regulation of mitotic cell cycle
negative regulation of gene expression
viral process
covalent chromatin modification
androgen receptor signaling pathway
sister chromatid biorientation
neuron projection development
maintenance of mitotic sister chromatid cohesion
glial cell apoptotic process
skeletal muscle cell differentiation
neuron maturation
enucleate erythrocyte differentiation
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of lipid kinase activity
myoblast differentiation
positive regulation of macrophage differentiation
positive regulation of mitotic metaphase/anaphase transition
negative regulation of smoothened signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
cell morphogenesis involved in neuron differentiation
negative regulation of epithelial cell proliferation
striated muscle cell differentiation
cell division
neuron apoptotic process
protein localization to chromosome, centromeric region
cellular response to xenobiotic stimulus
regulation of cohesin loading
negative regulation of transcription involved in G1/S transition of mitotic cell cycle
regulation of centromere complex assembly
hepatocyte apoptotic process
negative regulation of G1/S transition of mitotic cell cycle
positive regulation of transcription regulatory region DNA binding
