Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 3
Phospho-STAT5 alpha/beta (Ser726, Ser731) Antibody (PA5-36767) in IHC (P)
Immunohistochemical analysis of Phospho-STAT5 alpha pSer726+STAT5 beta pSer731 in paraffin-embedded human breast carcinoma using Phospho-STAT5 alpha pSer726+STAT5 beta pSer731 polyclonal antibody (Product # PA5-36767) at a dilution of 1:100.
产品信息
PA5-36767
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide derived from human Stat5a around the phosphorylation site of Serine 726
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2553715
产品详细信息
This antibody detects endogenous protein at a molecular weight of 90 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Mammary gland factor; mammary gland factor STAT5A; mammary gland factor STAT5B; signal transducer and activator of transcription 5; Signal transducer and activator of transcription 5A; Signal transducer and activator of transcription 5B; STA5B; STAT; transcription factor STAT5B
基因别名: AA959963; MGF; Mpf; STAT5; STAT5A; STAT5B
UniProt ID: (Human) P42229, (Human) P51692, (Rat) Q62771, (Mouse) P42230, (Rat) P52632, (Mouse) Q541Q5
Entrez Gene ID: (Human) 6776, (Human) 6777, (Rat) 24918, (Mouse) 20850, (Rat) 25126, (Mouse) 20851
DNA binding
transcription factor activity, sequence-specific DNA binding
protein tyrosine kinase activity
signal transducer activity
protein binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
protein phosphatase binding
glucocorticoid receptor binding
protein dimerization activity
double-stranded DNA binding
sequence-specific DNA binding
DNA-binding transcription factor
allantoin metabolic process
positive regulation of endothelial cell proliferation
citrate metabolic process
2-oxoglutarate metabolic process
succinate metabolic process
oxaloacetate metabolic process
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
isoleucine metabolic process
valine metabolic process
creatine metabolic process
fatty acid metabolic process
JAK-STAT cascade
lactation
peptidyl-tyrosine phosphorylation
taurine metabolic process
prolactin signaling pathway
regulation of multicellular organism growth
positive regulation of blood vessel endothelial cell migration
creatinine metabolic process
JAK-STAT cascade involved in growth hormone signaling pathway
luteinization
response to hypoxia
natural killer cell differentiation
liver development
transcription from RNA polymerase II promoter
acute-phase response
female pregnancy
regulation of steroid metabolic process
lipid storage
regulation of epithelial cell differentiation
response to estradiol
response to lipopolysaccharide
positive regulation of natural killer cell proliferation
positive regulation of natural killer cell differentiation
cellular response to hormone stimulus
T cell differentiation in thymus
positive regulation of multicellular organism growth
positive regulation of activated T cell proliferation
progesterone metabolic process
T cell homeostasis
negative regulation of apoptotic process
positive regulation of interleukin-2 biosynthetic process
response to ethanol
positive regulation of B cell differentiation
positive regulation of gamma-delta T cell differentiation
negative regulation of erythrocyte differentiation
positive regulation of erythrocyte differentiation
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
positive regulation of natural killer cell mediated cytotoxicity
development of secondary female sexual characteristics
development of secondary male sexual characteristics
Peyer's patch development
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
positive regulation of cellular component movement
response to interleukin-2
response to interleukin-4
response to interleukin-15
cellular response to growth factor stimulus
cellular response to epidermal growth factor stimulus
mast cell migration
regulation of transcription, DNA-templated
signal transduction
positive regulation of cell proliferation
cytokine-mediated signaling pathway
regulation of cell adhesion
mammary gland development
response to nutrient levels
negative regulation of mast cell apoptotic process
response to peptide hormone
positive regulation of lymphocyte differentiation
multicellular organismal reproductive process
mammary gland involution
positive regulation of mast cell differentiation
prostate gland epithelium morphogenesis
epithelial cell differentiation involved in prostate gland development
mammary gland epithelium development
positive regulation of mast cell proliferation
cellular response to granulocyte macrophage colony-stimulating factor stimulus
sex differentiation
