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Invitrogen
Phospho-STING (Ser366) Polyclonal Antibody
高级验证
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
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Phospho-STING (Ser366) Antibody (PA5-117276) in WB
Knockout of STING was achieved by CRISPR-Cas9 genome editing using LentiArray™ Lentiviral sgRNA (Product # A32042, Assay ID CRISPR802256_LV) and LentiArray Cas9 Lentivirus (Product # A32064). Western blot analysis of STING was performed by loading 30 µg of THP-1 Cas9 (Lane 1) and THP-1 STING KO (Lane 2) membrane enriched extracts. The samples were electrophoresed using NuPAGE™ Novex™ 4-12% Bis-Tris Protein ... View More
产品信息
PA5-117276
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic phosphorylated peptide around S366 of human STING/TMEM173 (NP_9380231)
偶联物
形式
Liquid
浓度
0.08 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901906
产品详细信息
Positive Samples: THP-1
Immunogen sequence: LISGME
靶标信息
STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: endoplasmic reticulum IFN stimulator; Endoplasmic reticulum interferon stimulator; ERIS; hMITA; hSTING; Mediator of IRF3 activation; mitochondrial mediator of IRF3 activation; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; Stimulator of interferon genes protein; tm173; Transmembrane protein 173
基因别名: ERIS; hMITA; hSTING; MITA; MPYS; NET23; SAVI; STING; STING1; TMEM173
UniProt ID: (Human) Q86WV6
Entrez Gene ID: (Human) 340061
activation of innate immune response
positive regulation of defense response to virus by host
apoptotic process
positive regulation of protein binding
regulation of type I interferon production
positive regulation of type I interferon production
interferon-beta production
positive regulation of protein import into nucleus, translocation
cellular response to interferon-beta
positive regulation of transcription factor import into nucleus
innate immune response
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
cellular response to exogenous dsRNA
cellular response to organic cyclic compound
