Invitrogen

Phospho-TRPV1 (Ser502) Polyclonal Antibody

Phospho-TRPV1 (Ser502) Antibody in Western Blot (WB)

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Phospho-TRPV1 (Ser502) Antibody (PA5-64860) in WB

Marine drugs 2023 - Effect of porphyra 334 on TRPV1 signaling induced by UPM. ( a ) In experiments in which HaCaT cells were treated with UPM (50 mug/mL) for 90 min, porphyra 334 (100 mum) was co-treated for 30 min, 60 min, and 90 min, respectively. After 90 min, the cells were harvested and the phosphorylated form of TRPV1 was detected using Western blot analysis. ( b ) The Fluo-4 NW assay was used to assess calcium influx in... View More

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产品信息

PA5-64860

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human TRPV1 (Phospho-Ser502)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2663797

产品详细信息

Phospho-TRPV1 (Ser502) Polyclonal Antibody detects endogenous levels of TRPV1 only when phosphorylated at Ser502.

靶标信息

TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons. TRPV1 is a non-selective cation channel that is structurally related to members of the TRP family of ion channels such as TRPC3 and TRPC6. TRPV1 is permeable to calcium, magnesium, and monovalent cations of sodium and potassium. Structurally, TRPV1 contains 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains. TRPV1 is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. TRPV1 seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. The expression of TRPV1 appears to be limited to neurons within the sensory ganglia. Four transcript variants encoding TRPV1 with variations in th 5' UTR sequence have been described. Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Anti-Pollutant Activity of Porphyra yezoensis Water Extract and Its Active Compound, Porphyra 334, against Urban Particulate Matter-Induced Keratinocyte Cell Damage.

Marine drugs

Choi S,Lee JH,Oh SW,Yu E,Kwon K,Jang SJ,Shin DS,Moh SH,Lee J

PA5-64860 was used in Western Blotting to reveal that the increased ROS levels induced by UPM treatment induced transient receptor potential vanilloid 1 (TRPV1) activity, which is related to skin aging and inflammatory responses.

Mon Feb 13 00:00:00 EST 2023

Anti-Pollutant Activity of Porphyra yezoensis Water Extract and Its Active Compound, Porphyra 334, against Urban Particulate Matter-Induced Keratinocyte Cell Damage.

Marine drugs

Choi S,Lee JH,Oh SW,Yu E,Kwon K,Jang SJ,Shin DS,Moh SH,Lee J

Mon Feb 13 00:00:00 EST 2023

Yellow Chaste Weed and Its Components, Apigenin and Galangin, Affect Proliferation and Oxidative Stress in Blue Light-Irradiated HaCaT Cells.

Nutrients

Park JY,Park SH,Oh SW,Kwon K,Yu E,Choi S,Yang S,Han SB,Jung K,Song M,Cho JY,Lee J

Published figure using Phospho-TRPV1 (Ser502) polyclonal antibody (Product # PA5-64860) in Western Blot

Sun Mar 13 00:00:00 EST 2022

Inhibition of carrageenan-induced dental inflammatory responses owing to decreased TRPV1 activity by Dexmedetomidine.

Journal of inflammation (London, England)

Lv G,Zhu G,Xu M,Gao X,Xiao Q

PA5-64860 was used in Western Blotting to study the inhibitory effect of Dexmedetomidine (Dex) on inflammation in dental pulp cells.

Thu Apr 14 00:00:00 EDT 2022

Inhibition of carrageenan-induced dental inflammatory responses owing to decreased TRPV1 activity by Dexmedetomidine.

Journal of inflammation (London, England)

Lv G,Zhu G,Xu M,Gao X,Xiao Q

PA5-64860 was used in Western Blotting to study the inhibitory effect of Dexmedetomidine (Dex) on inflammation in dental pulp cells.

Thu Apr 14 00:00:00 EDT 2022

PKCε SUMOylation Is Required for Mediating the Nociceptive Signaling of Inflammatory Pain.

Cell reports

Zhao X,Xia B,Cheng J,Zhu MX,Li Y

PA5-64860 was used in Western Blot to conclude that the SUMOylation of PKCε potentiates inflammatory thermal hyperalgesia through stabilizing the interaction with TRPV1 to enhance its function by phosphorylation.

Tue Oct 06 00:00:00 EDT 2020

生物信息学

蛋白别名: Capsaicin receptor; cation channel; DKFZp434K0220; Osm-9-like TRP channel 1; OTRPC1; Transient receptor potential cation channel subfamily V member 1; transient receptor potential cation channel V1; transient receptor potential cation channel, subfamily V, member 1; transient receptor potential vanilloid 1 supraoptic nucleus; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; TrpV1; Vanilloid receptor; Vanilloid receptor 1; vanilloid receptor subtype 1; vanilloid receptor type 1 like protein 1; Vanilloid receptor type 1-like; vanilloid type 1 receptor

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基因别名: OTRPC1; TRPV1; TRPV1_SON; TRPV1alpha; TRPV1beta; VR-1; VR.5'sv; VR1; Vr1l; Vr1l1

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UniProt ID: (Human) Q9NQ74, (Rat) O35433, (Mouse) Q704Y3

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Entrez Gene ID: (Human) 7442, (Rat) 83810, (Mouse) 193034

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功能