Invitrogen

Phospho-TrkB (Tyr817) Recombinant Rabbit Monoclonal Antibody (SC0556)

查看其他53个TrkB抗体
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说明书
实验方案
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产品信息

MA5-32207

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:5,000
-

免疫组化（石蜡） (IHC (P))

1:1,000
-

免疫细胞化学 (ICC/IF)

1:50-1:200
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

SC0556

抗原

Synthetic phospho-peptide corresponding to residues surrounding Tyr817 of Human TrkB aa 789-822
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2809494

产品详细信息

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses. TrkB is involved in the development and maintenance of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: AI848316; BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; C030027L06Rik; EC 2.7.10.1; GP145 TrkB; GP145-TrkB; GP145-TrkB/GP95-TrkB; GP145TrkB; GP95 TrkB; GP95-TrkB; hyperphagia; kinase TrkB; neural receptor protein-tyrosine kinase (trkB); Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; NTRK 2; OTTHUMP00000021573; OTTHUMP00000021574; OTTHUMP00000021576; OTTHUMP00000021577; Trk B; Trk-B; TrkB tyrosine kinase; Tropomyosin-related kinase B; tyrosine kinase receptor B

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基因别名: GP145-TrkB; GP145-TrkB/GP95-TrkB; NTRK2; RATTRKB1; Tkrb; trk-B; TRKB; TRKB1

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UniProt ID: (Human) Q16620, (Mouse) Q3TUF9, (Rat) Q63604

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Entrez Gene ID: (Human) 4915, (Mouse) 18212, (Rat) 25054

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功能
ATP binding receptor tyrosine kinase binding protein homodimerization activity neurotrophin binding brain-derived neurotrophic factor binding brain-derived neurotrophic factor-activated receptor activity nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity neurotrophin receptor activity protein binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups ephrin receptor binding transmembrane signal receptor immunoglobulin superfamily cell adhesion molecule
参与通路
vasculogenesis neuron migration positive regulation of protein phosphorylation inflammatory response neuromuscular junction development aging learning long-term memory circadian rhythm feeding behavior positive regulation of cell proliferation response to light stimulus positive regulation of gene expression positive regulation of neuron projection development response to auditory stimulus glutamate secretion positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation central nervous system neuron development cerebral cortex development neuron differentiation brain-derived neurotrophic factor receptor signaling pathway positive regulation of peptidyl-serine phosphorylation calcium-mediated signaling using intracellular calcium source neurotrophin signaling pathway mechanoreceptor differentiation regulation of GTPase activity positive regulation of MAPK cascade negative regulation of neuron apoptotic process retinal rod cell development protein autophosphorylation regulation of neurotransmitter secretion oligodendrocyte differentiation peripheral nervous system neuron development positive regulation of axonogenesis regulation of dendrite development regulation of protein kinase B signaling positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic retina development in camera-type eye long-term synaptic potentiation cellular response to amino acid stimulus cellular response to tumor necrosis factor cellular response to brain-derived neurotrophic factor stimulus negative regulation of anoikis protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development phosphorylation regulation of metabolic process cell differentiation regulation of MAPK cascade positive regulation of glucocorticoid receptor signaling pathway cellular response to nerve growth factor stimulus
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