Invitrogen

Phospho-UBF-1 (Ser484) Polyclonal Antibody

Phospho-UBF-1 (Ser484) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Phospho-UBF-1 (Ser484) Antibody (PA5-40183) in IHC (P)

Immunohistochemical analysis of Phospho-UBF-1 (Ser484) in Human breast carcinoma tissue using paraffin-embedded Phospho-UBF-1 (Ser484) Polyclonal Antibody (Product # PA5-40183). The picture on the right is treated with the synthesized peptide.

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产品信息

PA5-40183

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

免疫组化（石蜡） (IHC (P))

1:50-1:100

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide sequence around phosphorylation site of serine 484 (P-E-S(p)-P-K) derived from Human UBF.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2609324

产品详细信息

This antibody is predicted to react with mouse and rat based on sequence homology.

靶标信息

UBF-1 encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 90-kDa nucleolus organizer region autoantigen; Autoantigen NOR-90; NOR90; Nucleolar transcription factor 1; transcription factor UBF; UBF-1; Upstream-binding factor 1

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基因别名: A930005G04Rik; NOR-90; Tcfubf; UBF; UBF-1; UBF1; UBF2; UBTF

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UniProt ID: (Human) P17480, (Rat) P25977

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Entrez Gene ID: (Human) 7343, (Rat) 25574, (Mouse) 21429

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功能

RNA polymerase I CORE element sequence-specific DNA binding RNA polymerase I upstream control element sequence-specific DNA binding protein binding poly(A) RNA binding DNA binding chromatin binding DNA-binding transcription factor

参与通路

regulation of transcription from RNA polymerase I promoter transcription from RNA polymerase I promoter transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase I promoter termination of RNA polymerase I transcription positive regulation of transcription from RNA polymerase I promoter regulation of glucose mediated signaling pathway chromatin silencing at rDNA chromatin remodeling regulation of transcription, DNA-templated