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产品信息
PA5-64824
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human EIF6 (Phospho-Ser235)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2663008
产品详细信息
Phospho-eIF6 (Ser235) Polyclonal Antibody detects endogenous levels of eIF6 only when phosphorylated at Ser235.
靶标信息
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding two different isoforms have been found for this gene.
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生物信息学
蛋白别名: B(2)GCN homolog; B4 integrin interactor; CAB; eIF-6; eIF-6 {ECO:0000255|HAMAP-Rule:MF_03132}; EIF6; eukaryotic translation initiation factor 3A; Eukaryotic translation initiation factor 6; eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132}; integrin beta 4 binding protein; p27 beta-4 integrin-binding protein; p27(BBP)
基因别名: 1110004P11; AA408895; b(2)gcn; CAB; eIF-6; EIF3A; EIF6; imc-415; ITGB4BP; OK/SW-cl.27; p27(BBP); p27BBP
UniProt ID: (Human) P56537, (Rat) Q3KRD8, (Mouse) O55135
Entrez Gene ID: (Human) 3692, (Rat) 305506, (Mouse) 16418
ribosomal subunit export from nucleus
maturation of 5.8S rRNA
maturation of LSU-rRNA
regulation of glycolytic process
translational initiation
response to insulin
gene silencing by miRNA
miRNA mediated inhibition of translation
mature ribosome assembly
regulation of fatty acid biosynthetic process
regulation of megakaryocyte differentiation
positive regulation of translation
assembly of large subunit precursor of preribosome
regulation of reactive oxygen species metabolic process
ribosomal large subunit biogenesis
translation
ribosome biogenesis
