Invitrogen

Plasminogen Polyclonal Antibody

Plasminogen Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Plasminogen Antibody (PA5-34677) in IHC (P)

Immunohistochemistry (Paraffin) analysis of Plasminogen was performed in paraffin-embedded rat prostate tissue using Plasminogen Polyclonal Antibody (Product # PA5-34677) at a dilution of 1:500.

Plasminogen Antibody in Western Blot (WB)

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产品信息

PA5-34677

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

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免疫组化（石蜡） (IHC (P))

1:100-1:1,000

免疫细胞化学 (ICC/IF)

1:100-1:1,000

酶联免疫吸附实验 (ELISA)

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竞争反应 (CA)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fragment corresponding to a region within amino acids 84 and 434 of Plasminogen (Uniprot ID#P00747)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.18 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 1% BSA, 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2552029

产品详细信息

Recommended positive controls: Jurkat, Raji, K562, BCL-1, PC-12, Rat2, human plasma, mouse plasma, rat plasma.

Predicted reactivity: Rat (80%), Dog (81%), Pig (80%), Rhesus Monkey (93%), Bovine (81%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Plasminogen is a plasma protein synthesized mostly in the liver. It consists of a single polypeptide chain and has a molecular weight of 88.5 kDa. The plasma concentration is usually in the range of 70 - 200 mg/L. Plasminogen is activated by tissue-plasminogen activator, urokinase and streptokinase, to form plasmin. Activation results from the cleavage and release of the preactivation peptide. Plasmin consists of a heavy (A-) chain which contains 5 kringles and a light (B-) chain with the active site. Plasmin is a trypsin-like protease whose natural substrate is fibrin, with binding sites for fibrin residing on the kringles. Plasmin is essential for fibrinolysis and decreased fibrinolytic potential due to congenital defects in plasmin can lead to recurring thrombosis, thrombophlebitis and pulmonary embolism.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Schistosoma mansoni phosphoglycerate mutase: a glycolytic ectoenzyme with thrombolytic potential.

Parasite (Paris, France)

Pirovich DB,Da'dara AA,Skelly PJ

PA5-34677 was used in Competition assay to support the hypothesis that host-interactive tegumental proteins (such as SmPGM), by enhancing plasmin formation, may help degrade blood clots around the worms in the vascular microenvironment and thus promote parasite survival in vivo.

Tue Sep 13 00:00:00 EDT 2022

Longitudinal proteomics study of serum changes after allogeneic HSCT reveals potential markers of metabolic complications related to aGvHD.

Scientific reports

Wong SY,Kato S,Rodenburg F,Tojo A,Hayashi N

Published figure using Plasminogen polyclonal antibody (Product # PA5-34677) in Western Blot

Wed Aug 17 00:00:00 EDT 2022

PLG inhibits Hippo signaling pathway through SRC in the hepatitis B virus-induced hepatocellular-carcinoma progression.

American journal of translational research

Hu ZG,Chen YB,Huang M,Tu JB,Tu SJ,Pan YJ,Chen XL,He SQ

PA5-34677 was used in Western Blot to suggest PLG may be an activator of HBV-infected hepatocellular carcinoma development, as a novel prognostic biomarker and therapeutic target for HBV-HCC.