Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 4
Plexin-A3 (extracellular) Antibody (APR-093-200UL) in IHC (F)
Expression of Plexin-A3 in mouse parietal cortex - Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-Plexin-A3 (extracellular) Antibody (#APR-093), (1:200), followed by goat- Anti-rabbit-AlexaFluor-488. PLXNA3 staining (green) appears in pyramidal neurons (arrows). Cell nuclei are stained with DAPI (blue).
产品信息
APR-093-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)KVRVDGSQDAQLYE, corresponding to amino acid residues 440-453 of mouse PLXNA3, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: plexin 3; Plexin 4, SEX, homolog to the cMet/HGF receptors; Plexin-4; Plexin-A3; Semaphorin receptor SEX; Sex chromosome X transmembrane protein of HGF receptor family 3; SEXPLEXIN-A3
基因别名: 6.3; HSSEXGENE; mKIAA4078; PlexA3; Plxa3; PLXN3; PLXN4; PLXNA3; SEX; XAP-6
UniProt ID: (Human) P51805, (Mouse) P70208, (Rat) D3ZPX4
Entrez Gene ID: (Human) 55558, (Mouse) 18846, (Rat) 309280
signal transduction
axon guidance
facial nerve structural organization
trigeminal nerve structural organization
hippocampus development
branchiomotor neuron axon guidance
pyramidal neuron development
negative regulation of axon extension involved in axon guidance
negative chemotaxis
positive regulation of cytoskeleton organization
semaphorin-plexin signaling pathway involved in axon guidance
semaphorin-plexin signaling pathway
multicellular organism development
regulation of cell migration
regulation of axon extension involved in axon guidance
neuron projection extension
