Bethyl Laboratories

Presenilin-2 Polyclonal Antibody

Presenilin-2 Antibody in Immunohistochemistry (IHC)

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Presenilin-2 Antibody (A304-342A) in IHC

Detection of human Presenilin-2 by immunohistochemistry. Sample: FFPE section of human lung cancer. Antibody: Affinity purified rabbit anti- Presenilin-2 (Cat. No. A304-342A Lot1) used at a dilution of 1:1,000 (1µg/ml). Detection: DAB.

Presenilin-2 Antibody in Western Blot (WB)

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产品信息

A304-342A

应用

建议稀释比

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免疫印迹 (WB)

1:1,000-1:5,000

免疫组化 (IHC)

1:500-1:2,000

免疫沉淀 (IP)

2-10 µg/mg lysate

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Region between residue 275 to 325 of Human Presenilin 2.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

tris citrate/phosphate, pH 7-8

内含物

0.09% sodium azide

保存条件

4° C

运输条件

Wet ice

产品详细信息

The recommended shelf life for this product is 1 year from date of receipt.

Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, Pig and Orangutan

靶标信息

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

仅用于科研。不用于诊断过程。未经明确授权不得转售。