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Progranulin Antibody (MA1-187) in IHC
Immunohistochemistry analysis of progranulin was performed on human kidney tissue and is showing positive staining (left panel). To expose target proteins, antigen retrieval was performed by microwaving tissues for 15 minutes in 10mM sodium citrate buffer (pH 6.0). Tissue slides were probed with progranulin monoclonal antibody (Product # MA1-187) at a dilution of 1:20, over night at 4C in a humidified chamb... View More
产品信息
MA1-187
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2D4-2F1
抗原
Recombinant human Progranulin
偶联物
Unconjugated
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Protein A
保存液
PBS with 1mg/mL BSA, 30% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2536878
产品详细信息
By Western blot, MA1-187 detects Human Progranulin at ~85 kDa.
靶标信息
Progranulin is the precursor protein of Granulin also called as Proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature Granulin. Both Granulin and smaller cleavage product of Granulin regulates cell growth. Progranulin stimulates proliferation of many epithelial cells, promotes their anchorage-independent growth and, when overexpressed, confers epithelial tumorigenicity. Progranulin/epithelin gene is multifunctional, with important constitutive roles in epithelial homeostasis, reproductive, immunological, and neuronal function. Progranulin constitutively expressed in a number of epithelia, particularly in the skin, GI tract, and reproductive system. Progranulin is expressed in immune cells in vivo and in specific neurons in the brain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Acrogranin; Epithelin precursor; Glycoprotein of 88 Kda; GP88; Granulin precursor; granulin-epithelin; PC cell-derived growth factor; PCDGF; PEPI; PGRN; Proepithelin; Progranulin
基因别名: CLN11; GEP; GP88; GRN; PCDGF; PEPI; PGRN
UniProt ID: (Human) P28799
Entrez Gene ID: (Human) 2896
