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产品信息
PA5-120704
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RAB11A/RAB11B (NP_0046541)
偶联物
Unconjugated
形式
Liquid
浓度
1.507 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2914276
产品详细信息
Positive test controls include: A-549, Mouse brain, Mouse heart, Rat liver, Rat heart.
Immunogen sequence: MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE
靶标信息
Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 24KG; GTP-binding protein YPT3; RAB 11A, member oncogene family; Rab-11; RAB11B, member of RAS oncogene family; RAS oncogene family protein; Ras-related protein Rab-11A; Ras-related protein Rab-11B; YL8
基因别名: A730055L17Rik; H-YPT3; RAB11; RAB11A; RAB11B; YL8; YPT3
UniProt ID: (Human) P62491, (Human) Q15907, (Rat) P62494, (Mouse) P62492, (Rat) O35509, (Mouse) P46638
Entrez Gene ID: (Human) 8766, (Human) 9230, (Rat) 81830, (Mouse) 53869, (Rat) 79434, (Mouse) 19326
intracellular protein transport
exocytosis
mitotic metaphase plate congression
metabolic process
positive regulation of epithelial cell migration
regulation of multivesicular body size
positive regulation of G2/M transition of mitotic cell cycle
vesicle-mediated transport
astral microtubule organization
neuron projection development
melanosome transport
Rab protein signal transduction
multivesicular body assembly
positive regulation of axon extension
regulation of long-term neuronal synaptic plasticity
regulation of protein transport
establishment of vesicle localization
regulation of vesicle-mediated transport
establishment of protein localization to organelle
protein localization to plasma membrane
establishment of protein localization to membrane
mitotic spindle assembly
exosomal secretion
receptor recycling
small GTPase mediated signal transduction
transferrin transport
insulin secretion involved in cellular response to glucose stimulus
regulation of anion transport
constitutive secretory pathway
regulated exocytosis
cellular response to acidic pH
cell-cell adhesion
retrograde transport, endosome to plasma membrane
regulation of protein localization to cell surface
regulation of endocytic recycling
endocytosis
cytokinesis
renal water homeostasis
protein transport
plasma membrane to endosome transport
transport
cell cycle
