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产品信息
PA5-55300
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2646232
产品详细信息
Immunogen sequence: LDSKLTLPNG EPVPCLLLAN KCDLSPWAVS RDQIDRFSKE NGFTGWTETS VKENKNINEA MRVLIEKMMR NSTEDIMSLS TQGDYINLQT KS
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 91%.
靶标信息
Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection. {ECO:0000269; PubMed:22042847, ECO:0000269; PubMed:24788816}.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Rab-7-like protein 1; RAB7, member RAS oncogene family-like 1; Ras-related protein Rab-29; Ras-related protein Rab-7L1
基因别名: RAB29; RAB7L; RAB7L1
UniProt ID: (Human) O14966
Entrez Gene ID: (Human) 8934
ER to Golgi vesicle-mediated transport
Golgi to endosome transport
Golgi organization
small GTPase mediated signal transduction
response to bacterium
negative regulation of neuron projection development
symbiont intracellular protein transport in host
melanosome organization
retrograde transport, plasma membrane to Golgi
retrograde transport, endosome to Golgi
protein localization to membrane
positive regulation of intracellular protein transport
regulation of neuron death
