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Application
FIGURE: 1 / 4
RAB3d Antibody (PA5-119839) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded human prostate tissue using RAB3d Polyclonal Antibody (Product # PA5-119839). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the RAB3d antibody at a dilution of 1:... View More
Product Details
PA5-119839
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within human Rab3D aa 64-219
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913411
Product Specific Information
Positive Control: Mouse pancreas tissue lysate, rat pancreas tissue lysate, PC-3 cell lysates, rat pancreas tissue, human prostate tissue.
Subcellular Location: Cell membrane.
Target Information
Rab proteins are low-molecular-weight GTP-binding proteins that form the largest branch of the Ras superfamily of GTPases. Located on the cytoplasmic face of organelles and vesicles, rab proteins are involved in intracellular membrane fusion reactions. Three membrane proteins, synaptosomal associated protein of 25 kDa (SNAP-25), synaptobrevin, and syntaxin, form the core of a ubiquitous membrane fusion machine that interacts with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and a-SNAP. Rab proteins, in coordination with the core fusion machinery and Munc-18, help to mediate vesicle docking and fusion. There exist over 40 rab proteins that have been described in mammals. Rab 3D has been shown to be present, in part, in the tongue, pancreas, and liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glioblastoma overexpressed; GTP-binding protein Rab-3D; Rab3D upregulated with myeloid differentiation; Ras-related protein Rab-3D
Gene Aliases: C130057E11Rik; D2-2; GOV; RAB16; RAB3D; RAD3D
UniProt ID: (Human) O95716, (Mouse) P35276, (Rat) Q63942
Entrez Gene ID: (Human) 9545, (Mouse) 19340, (Rat) 140665
exocytosis
small GTPase mediated signal transduction
protein transport
peptidyl-cysteine methylation
bone resorption
positive regulation of regulated secretory pathway
transport
intracellular protein transport
vesicle docking involved in exocytosis
protein secretion
synaptic vesicle exocytosis
regulation of exocytosis
Rab protein signal transduction
protein localization to plasma membrane
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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