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产品信息
PA5-36509
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 231-278 of Human Rab 40B.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2553559
产品详细信息
This antibody detects endogenous protein at a molecular weight of 34 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
Rab 40B is a 278 amino acid protein that belongs to the small GTPase superfamily and the Rab family. Rab 40B contains a SOCS box domain that mediates interactions with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. Rab 40B shares similarity with a yeast protein, suggesting a role in regulation of secretory vesicles. The Rab 40B gene is conserved in chimpanzee, cow, mouse, rat, chicken and zebrafish, and maps to human chromosome 17q25.3. It has been suggested that there is a major gene locus on chromosome 17q25.3 for autosomal dominant moyamoya disease (MMD), which is an idiopathic steno-occlusive cerebrovascular disease that represents an important cause of stroke.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GTP-binding protein homologous to Saccharomyces cerevisiae SEC4; Protein Rar; RAR SOCS box containing protein; Ras-related protein Rab-40B; sec4; SOCS box-containing protein RAR
基因别名: RAB40B; RAR; SEC4L
UniProt ID: (Human) Q12829, (Mouse) Q8VHP8
Entrez Gene ID: (Human) 10966, (Rat) 303754, (Mouse) 217371
intracellular protein transport
vesicle docking involved in exocytosis
protein secretion
protein ubiquitination
regulation of exocytosis
Rab protein signal transduction
protein localization to plasma membrane
small GTPase mediated signal transduction
symbiont intracellular protein transport in host
protein transport
intracellular signal transduction
