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RAB7A Antibody (PA5-72549) in IHC (P)
Immunohistochemistry analysis of RAB7A in paraformaldehyde-fixed, paraffin-embedded human skeletal muscle tissue sections. Samples were incubated with RAB7A polyclonal antibody (Product # PA5-72549) using a dilution of 1:25 for 1 hours at 37°C followed by an undiluted biotinylated goat polyvalent antibody. Tissue was fixed with formaldehyde and blocked with 3% BSA for 0.5 hour at room temperature; antigen r... View More
产品信息
PA5-72549
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 176-204 amino acids from the C-terminal region of human RAB7
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2718403
靶标信息
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: rab-7; RAB7, member RAS oncogene family; Ras-associated protein RAB7; Ras-related protein BRL-RAS; Ras-related protein p23; Ras-related protein Rab-7a
基因别名: PRO2706; RAB7; RAB7A
UniProt ID: (Human) P51149, (Mouse) P51150, (Rat) P09527
Entrez Gene ID: (Human) 7879, (Mouse) 19349, (Rat) 29448
protein targeting to lysosome
transport
intracellular protein transport
epidermal growth factor catabolic process
small GTPase mediated signal transduction
endosome to lysosome transport
protein transport
viral release from host cell
protein to membrane docking
Rab protein signal transduction
retrograde transport, endosome to Golgi
early endosome to late endosome transport
bone resorption
positive regulation of protein catabolic process
positive regulation of viral process
phagosome acidification
phagosome-lysosome fusion
positive regulation of exosomal secretion
regulation of autophagosome assembly
endocytosis
antigen processing and presentation of exogenous peptide antigen via MHC class II
lipophagy
phagosome maturation
