Target of Interest
Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-88904
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 466-616 of human TNFRSF11A (NP_0038301)
偶联物
Unconjugated
形式
Liquid
浓度
0.81 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2805208
产品详细信息
Immunogen sequence: RGPLPQCAYG MGLPPEEEAS RTEARDQPED GADGRLPSSA RAGAGSGSSP GGQSPASGNV TGNSNSTFIS SGQVMNFKGD IIVVYVSQTS QEGAAAAAEP MGRPVQEETL ARRDSFAGNG PRFPDPCGGP EGLREPEKAS RPVQEQGGAK A; Positive Samples: HT-29, Mouse brain, Rat kidney; Cellular Location: Cell membrane, Single-pass type I membrane protein
靶标信息
RANK is a member of the tumor necrosis factor receptor (TNFR) family. The full length mouse RANK cDNA encodes a type I transmembrane protein with an extracellular and a cytoplasmic domain. The extracellular domain contains two potential N-linked glycosylation sites. RANK shares significant amino acid homology with other members of the TNFR family in its extracellular four cysteine-rich repeats. Human and murine RANK share 81% amino acid identity in their extracellular domains.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: CD265; loss of heterozygosity, 18, chromosomal region 1; ODFR; Osteoclast differentiation factor receptor; Paget disease of bone 2; receptor activator of NF-kappaB; Receptor activator of NF-KB; receptor activator of nuclear factor-kappa B; Tumor necrosis factor receptor superfamily member 11A; tumor necrosis factor receptor superfamily member 11a, NFKB activator; tumor necrosis factor receptor superfamily, member 11a, NFKB activator
基因别名: CD265; FEO; LOH18CR1; Ly109; mRANK; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; RGD1563614; TNFRSF11A; TRANCE-R; TRANCER
UniProt ID: (Human) Q9Y6Q6, (Mouse) O35305
Entrez Gene ID: (Human) 8792, (Mouse) 21934, (Rat) 498206
ossification
adaptive immune response
monocyte chemotaxis
inflammatory response
signal transduction
cell-cell signaling
positive regulation of cell proliferation
response to radiation
osteoclast differentiation
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
response to cytokine
response to tumor necrosis factor
regulation of apoptotic process
positive regulation of JUN kinase activity
lymph node development
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
circadian temperature homeostasis
mammary gland alveolus development
response to interleukin-1
positive regulation of fever generation by positive regulation of prostaglandin secretion
TNFSF11-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
apoptotic signaling pathway
multicellular organism development
programmed cell death
