Invitrogen

RARB Recombinant Rabbit Monoclonal Antibody (ARC1024)

高级验证

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

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说明书

实验方案

技术支持

说明书

实验方案

技术支持

抗体检测数据 (6)
高级验证 (2)

RARB Antibody in Immunocytochemistry (ICC/IF)

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RARB Antibody (MA5-35529) in ICC/IF

Immunofluorescence analysis of RARB was performed using 70% confluent log phase T-47D cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with RARB Recombinant Rabbit Monoclonal Antibody (ARC1024) (Product # MA5-35529) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor ... View More

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RARB Antibody — Antibody specificity was demonstrated by siRNA mediated knockdown of target protein. T-47D cells were transfected with RARB siRNA and RARA siRNA and a decrease in signal intensity was observed only in RARB SiRNA transfected sample in Western Blot application using Anti-RARB Recombinant Rabbit Monoclonal Antibody (ARC1024) (Product # MA5-35529). RARA and RARB are reported to be at a similar molecular weight. The knockdown only in RARB SiRNA transfected sample and not in RARA SiRNA transfected sample shows the specificity of this antibody. {KD}

产品信息

MA5-35529

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:10000-1:4000

免疫细胞化学 (ICC/IF)

1:50-1:200

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

ARC1024

抗原

A synthetic peptide corresponding to a sequence within amino acids 350-455 of human RARbeta.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.2 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2849429

产品详细信息

Immunogen sequence: KLQEPLLEAL KIYIRKRRPS KPHMFPKILM KITDLRSISA KGAERVITLK MEIPGSMPPL IQEMLENSEG HEPLTPSSSG NTAEHSPSIS PSSVENSGVS QSPLVQ

靶标信息

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: HBV-activated protein; hepatitis B virus activated protein; Nuclear receptor subfamily 1 group B member 2; RAR beta; RAR-b; RAR-beta; RAR-Beta2; RAR-Beta4; RAR-epsilon; retinoic acid; retinoic acid receptor; Retinoic acid receptor beta; retinoic acid receptor, beta polypeptide

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基因别名: A830025K23; HAP; MCOPS12; NR1B2; RARB; RARbeta1; RRB2

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UniProt ID: (Human) P10826, (Mouse) P22605

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Entrez Gene ID: (Human) 5915, (Mouse) 218772

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