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Positive Control: mouse brain, rat brain
Predicted reactivity: Rat (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
RASGRF1 is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. Studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ASPP1; CDC25Mm; GNRP; Guanine nucleotide-releasing protein; KIAA0771; P140 RAS-GRF; PPP1R13B; Ras guanine release factor beta; Ras-GRF1; Ras-specific guanine nucleotide-releasing factor 1; Ras-specific nucleotide exchange factor CDC25
基因别名: AI844718; CDC25; CDC25Mm; Gnrp; Grf1; Grfbeta; p190; P190-A; p190RhoGEF; Ras-GRF1; Rasgrf1
UniProt ID: (Mouse) P27671, (Rat) P28818
Entrez Gene ID: (Mouse) 19417, (Rat) 192213
分子生物学功能: guanyl-nucleotide exchange factor membrane traffic protein