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RASSF1 Antibody (PA5-102383) in IHC (P)
Immunohistochemistry analysis of RASSF1 in mouse brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with RASSF1 polyclonal antibody (Product # PA5-102383) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-102383
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human RASSF1(Accession Q9NS23), corresponding to amino acid residues G162-K212.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2851790
产品详细信息
Antibody detects endogenous levels of total RASSF1.
靶标信息
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 123F protein; cardiac-specific ras association domain family 1 protein; pancreas-specific ras association domain family 1 protein; Protein 123F2; Ras association (RalGDS/AF-6) domain family 1; Ras association (RalGDS/AF-6) domain family member 1; Ras association domain family 1; Ras association domain-containing protein 1; RASSF1; RASSF1A tumor suppressor; tumor suppressor protein RDA32; WUGSC:H_LUCA12.5
基因别名: 123F2; AA536941; AU044980; NORE2A; RASSF1; RASSF1A; Rassf1B; Rassf1C; RDA32; REH3P21
UniProt ID: (Human) Q9NS23, (Mouse) Q99MK9
Entrez Gene ID: (Human) 11186, (Mouse) 56289, (Rat) 363140
cell cycle arrest
Ras protein signal transduction
regulation of microtubule cytoskeleton organization
cellular response to DNA damage stimulus
cell cycle
signal transduction
positive regulation of protein ubiquitination
intracellular signal transduction
protein stabilization
negative regulation of cell cycle arrest
biological_process
