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Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 2810480G15Rik; RNA-binding motif protein 28; RNA-binding protein 28
基因别名: ANES; RBM28
UniProt ID: (Human) Q9NW13
Entrez Gene ID: (Human) 55131