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RCAN1 Antibody (PA5-142673) in ICC/IF
Immunocytochemistry analysis of paraformaldehyde fixed U2OS cells, permeabilized with 0.15% Triton. Samples were incubated with RCAN1 polyclonal antibody (Product # PA5-142673) using a dilution of 10 µg/mL for 1 hr followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL).
产品信息
PA5-142673
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-HIGSSHLAPPNPD.
偶联物
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2933319
产品详细信息
Additional Information: This antibody is expected to recognize all three reported isoforms (NP_004405.3; NP_981962.1; NP_981963.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
靶标信息
The RCAN1 protein interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: calcineurin inhibitor; Calcipressin-1; Down syndrome critical region protein 1 homolog; MCIP1; Myocyte-enriched calcineurin-interacting protein 1; Regulator of calcineurin 1
基因别名: Adapt78; CALP1L; CSP1; DSC1; Dscr1; MCIP1; Rcan1; RCN1
UniProt ID: (Mouse) Q9JHG6
Entrez Gene ID: (Mouse) 54720
response to ischemia
response to stress
response to oxidative stress
short-term memory
calcium-mediated signaling
locomotion involved in locomotory behavior
calcineurin-NFAT signaling cascade
regulation of phosphoprotein phosphatase activity
skeletal muscle fiber development
regulation of catalytic activity
regulation of calcineurin-NFAT signaling cascade
