Invitrogen

RDBP Polyclonal Antibody

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

查看其他11个RDBP抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

抗体检测数据 (7)
高级验证 (1)

RDBP Antibody in Immunohistochemistry (IHC)

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RDBP Antibody (PA5-52398) in IHC

Immunohistochemical staining of RDBP in human testis and skeletal muscle tissues using RDBP Polyclonal Antibody (Product # PA5-52398). Corresponding NELFE RNA-seq data are presented for the same tissues.

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RDBP Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of RDBP demonstrates antibody specificity. Immunohistochemical analysis of RDBP using anti-RDBP Polyclonal Antibody (Product # PA5-52398), shows significant staining of RDBP in human testis and shows minimal or weak staining in human skeletal muscle tissues. The relative expression levels of RDBP within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-52398

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化（石蜡） (IHC (P))

1:500-1:1,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human RDBP. Recombinant protein control fragment (Product #RP-89558).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.05 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2646440

产品详细信息

Immunogen sequence: LLALKKQSSS STTSQGGVKR SLSEQPVMDT ATATEQAKQL VKSGAISAIK AETKNSGFKR SRTLEGKLKD PEKGPVPTFQ PFQRSISADD DLQESSRRPQ RKSLYESFVS SSDRLRELGP DG

Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 94%.

靶标信息

RDBP is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: major histocompatibility complex gene RD; Negative elongation factor E; negative elongation factor polypeptide E; NELF E; NELF-E; nuclear protein; RD RNA binding protein; RD RNA-binding protein; RNA-binding protein RD

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基因别名: D6S45; NELF-E; NELFE; RD; RDBP; RDP

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UniProt ID: (Human) P18615

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Entrez Gene ID: (Human) 7936

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功能

nucleotide binding chromatin binding RNA binding protein binding poly(A) RNA binding

参与通路

transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter biological_process negative regulation of transcription elongation from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter positive regulation of viral transcription positive regulation of histone H3-K4 methylation positive regulation of ERK1 and ERK2 cascade negative regulation of mRNA polyadenylation