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REA Antibody (A300-657A-T) in WB
Detection of human and mouse REA by western blot. Samples: Whole cell lysate (15 µg) from HeLa, 293T, and mouse NIH3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-REA antibody A300-657A-M (lot A300-657A-M-2) used for WB at 1:1000. Detection: Chemiluminescence with an exposure time of 3 minutes.
产品信息
A300-657A-T
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Between 225 and 275
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine and Orangutan
靶标信息
PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B-cell associated protein; B-cell receptor-associated protein 37; B-cell receptor-associated protein BAP37; D-prohibitin; MGC117268; PHB2; Prohibitin-2; Repressor of estrogen receptor activity
基因别名: AU044498; BAP; Bap37; BCAP37; hBAP; p22; PHB2; PNAS-141; REA
UniProt ID: (Human) Q99623, (Mouse) O35129
Entrez Gene ID: (Human) 11331, (Mouse) 12034
protein import into nucleus, translocation
transcription, DNA-templated
regulation of transcription, DNA-templated
mitochondrion organization
sister chromatid cohesion
positive regulation of exit from mitosis
negative regulation of intracellular estrogen receptor signaling pathway
negative regulation of mammary gland epithelial cell proliferation
negative regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription, DNA-templated
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
mammary gland branching involved in thelarche
mammary gland alveolus development
regulation of branching involved in mammary gland duct morphogenesis
positive regulation of ERK1 and ERK2 cascade
positive regulation of cell cycle G1/S phase transition
regulation of complement activation
