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RFFL Antibody (PA5-54003) in WB
Western blot analysis of RFFL in control (vector only transfected HEK293T lysate) and RFFL over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells). Samples were probed using a RFFL Polyclonal Antibody (Product # PA5-54003).
产品信息
PA5-54003
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2646485
产品详细信息
Immunogen sequence: MKVKDLRDYL SLHDISTEMC REKEELVLLV LGQQPVISQE DRTRASTLSP DFPEQQAFLT QPHSSMVPPT SPNLPSSS^M
^M
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 86%.
靶标信息
Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CARP-2; Caspase regulator CARP2; Caspases-8 and -10-associated RING finger protein 2; E3 ubiquitin-protein ligase rififylin; Fring; FYVE-RING finger protein SAKURA; ring finger and FYVE-like domain containing 1; RING finger and FYVE-like domain-containing protein 1; RING finger protein 189; RING finger protein 34-like; RING-type E3 ubiquitin transferase rififylin
基因别名: CARP-2; CARP2; FRING; RFFL; RIFIFYLIN; RNF189; RNF34L
UniProt ID: (Human) Q8WZ73
Entrez Gene ID: (Human) 117584
ubiquitin-dependent protein catabolic process
apoptotic process
regulation of fibroblast migration
negative regulation of tumor necrosis factor-mediated signaling pathway
regulation of TOR signaling
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
protein K48-linked ubiquitination
negative regulation of signal transduction by p53 class mediator
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
