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RFX3 Antibody (PA5-57366) in ICC/IF
Immunofluorecent analysis of RFX3 in human cell line U-2 OS using RFX3 Polyclonal Antibody (Product # PA5-57366). Staining shows localization to nucleoplasm and vesicles.
产品信息
PA5-57366
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
形式
Liquid
浓度
0.08 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2646494
产品详细信息
Immunogen sequence: QYMAMRQQPM QQKQRYKPMQ KVDGVADGFT GSGQQTGTSV EQTVIAQSQH HQQFLDASRA LPEFGEVEIS SLPDGTTFED IKSLQSLYRE HCEAILDVVV NLQFSLIEKL WQTFWRYSPS TPTDGTTITE SSNLSE
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 100%.
靶标信息
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Two transcript variants encoding different isoforms have been described for this gene, and at least one of the variants utilizes alternative polyadenylation signals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bA32F11.1; DNA binding protein RFX3; Regulatory factor X 3; regulatory factor X, 3 (influences HLA class II expression); Transcription factor RFX3
基因别名: RFX3
UniProt ID: (Human) P48380
Entrez Gene ID: (Human) 5991
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription regulatory region DNA binding
winged helix/forkhead transcription factor
type B pancreatic cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
endocrine pancreas development
cilium assembly
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell maturation
regulation of insulin secretion
cilium-dependent cell motility
epithelial cilium movement involved in determination of left/right asymmetry
type B pancreatic cell maturation
positive regulation of type B pancreatic cell development
