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RFXANK Antibody (PA5-112689) in ICC/IF
Immunocytochemichal analysis of RFXANK in PC-3 cells using a Polyclonal antibody (Product # PA5-112689) at a dilution of 1:133. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L). Cells were also counter-stained with DAPI.
产品信息
PA5-112689
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human DNA-binding protein RFXANK protein (3-84AA)
偶联物
形式
Liquid
浓度
4.16 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2867424
靶标信息
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ankyrin repeat family A protein 1; ankyrin repeat-containing regulatory factor X-associated protein; DNA-binding protein RFXANK; Regulatory factor X subunit B; Regulatory factor X-associated ankyrin-containing protein; RFX-B; RFX-Bdelta4
基因别名: ANKRA1; BLS; F14150_1; RFX-B; RFXANK; RFXB
UniProt ID: (Human) Q24JQ1
Entrez Gene ID: (Human) 8625
