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产品信息
PA5-59553
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2646590
产品详细信息
Immunogen sequence: EVNELCQSVQ EHVELLGCGA GPQGEAAVRQ AEDAIQNANF SLSILPILYE AGSSPSHHWQ LGQKLEGLLR QVGEVCRQDI QDFTQ
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 92%.
靶标信息
RLTPR/CARMIL2 (RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing; capping protein regulator and myosin 1 linker 2), also known as LRRC16C, is a cytosolic protein, which with high affinity binds CAPZA2 (capping protein muscle actin Z-line alpha 2) and decreases CAPZA2 affinity for actin barbed ends. RLTPR/CARMIL2 increases the rate of actin filament elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Its interaction with CAPZA2 is essential for lamellipodial protrusion and cell translocation. RLTPR/CARMIL2 is crucial for T cell costimulation via CD28 and this property seems to be independent on its actin-uncapping function. The lack of functional RLTPR/CARMIL2 molecules impeded the differentiation toward Th1 and Th17 fates of both human and murine CD4+ T cells and leads to combined immunodeficiency. Expression of RLTPR/CARMIL2 was also detected in human and murine B cells, but it seems not to be involved in BCR-mediated signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Capping protein regulator and myosin 1 linker 2; Capping protein, Arp2/3 and myosin-I linker protein 2; F-actin-uncapping protein RLTPR; leucine rich repeat containing 16C; Leucine-rich repeat-containing protein 16C; RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing; RGD, leucine-rich repeat, tropomodulin and proline-rich containing protein; RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein
基因别名: CARMIL2; CARMIL2b; LRRC16C; RLTPR
UniProt ID: (Human) Q6F5E8
Entrez Gene ID: (Human) 146206
establishment or maintenance of cell polarity
positive regulation of lamellipodium assembly
maintenance of cell polarity
positive regulation of cell migration
positive regulation of T cell proliferation
wound healing, spreading of cells
establishment of protein localization
positive regulation of regulatory T cell differentiation
thymus development
homeostasis of number of cells
T cell receptor signaling pathway
actin filament network formation
establishment or maintenance of monopolar cell polarity
positive regulation of extracellular matrix disassembly
positive regulation of ruffle assembly
positive regulation of interleukin-2 secretion
positive regulation of interferon-gamma secretion
positive regulation of lamellipodium organization
negative regulation of barbed-end actin filament capping
