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Invitrogen
ROBO1 Polyclonal Antibody
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
产品信息
PA5-65752
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.10 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2665295
产品详细信息
Immunogen sequence: REVLDGRQVVD MRTNPGDPRE AQEQQNDGKG RGNKAAKRDL PPAKTHLIQE DILPYCRPTF PTSNNPRDPS SSSSMSSRGS GSRQREQANV GRRNIAEMQV LG
Highest antigen sequence identity to the following orthologs - mouse 92%, rat 89%.
靶标信息
Specialized cells at the midline, which separates the left and right halves of the CNS, have a number of roles in directing growth cone behavior. In the vertebrate spinal cord, the insect ventral nerve cord and in C. elegans, midline cells produce guidance cues such as nectins and slit, which act as attractants and repellents, respectively. These cells may act as gatekeepers to prevent axons from crossing the midline and to induce a switch in growth cone responsiveness to guidance cues beyond the gateway. One such gatekeeper, Robo, is an axon guidance receptor that defines a novel subfamily of Ig superfamily proteins that are conserved from fruit flies to mammals. Robo acts as a receptor for the repellent Slit and functions in a cell-autonomous fashion. Non-crossing axons express high levels of Robo, whereas crossing axons express low levels of Robo before reaching the midline and high levels after they cross. Robo1 and Robo2 are two human homologs of the Drosophila protein Roundabout. Robo1 is also homologous to the C. elegans gene sax3, whereas Robo2 is homologous to the zebrafish gene astray.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Deleted in U twenty twenty; FLJ21882; H-Robo-1; HGNC:10249; MGC131599; MGC133277; roundabout 1; Roundabout homolog 1; roundabout, axon guidance receptor, homolog 1
基因别名: DUTT1; ROBO1; SAX3
UniProt ID: (Human) Q9Y6N7
Entrez Gene ID: (Human) 6091
cell migration involved in sprouting angiogenesis
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
nervous system development
axon guidance
heart development
axon midline choice point recognition
chemorepulsion involved in postnatal olfactory bulb interneuron migration
negative regulation of cell migration
negative regulation of mammary gland epithelial cell proliferation
positive regulation of Rho protein signal transduction
Roundabout signaling pathway
positive regulation of axonogenesis
negative regulation of negative chemotaxis
negative regulation of chemokine-mediated signaling pathway
