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ROCK1/ROCK2 Antibody (MA5-50324) in IHC (P)
Immunohistochemical analysis of ROCK1/ROCK2 using ROCK1/ROCK2 Recombinant Monoclonal Antibody (Product # MA5-50324) in Paraffin embedded rat brain and colon tissue at a dilution of 1:200. For Antigen retrieval citrate buffer, pH 6.0, as used for 15 min.
产品信息
MA5-50324
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1632
抗原
Recombinant fragment of human ROCK1 .
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3093954
靶标信息
ROCK1 and ROCK2 are genes that encode for Rho-associated coiled-coil containing protein kinases, also known as ROCKs. These kinases are involved in a variety of cellular processes such as cell migration, adhesion, proliferation, and apoptosis. They are activated by the small GTPase RhoA and phosphorylate downstream targets such as myosin light chain, LIM kinase, and myosin phosphatase. Dysregulation of ROCK1 and ROCK2 has been linked to various diseases including cancer, cardiovascular disease, and neurological disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: p160 ROCK-1; p160ROCK; p164 ROCK-2; Renal carcinoma antigen NY-REN-35; Rho kinase 2; Rho-associated protein kinase 1; Rho-associated protein kinase 2; Rho-associated, coiled-coil containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase I; Rho-associated, coiled-coil-containing protein kinase II; ROCK-1/ROCK-2; ROCK-I; ROCK-I/ROCK-II; ROCK-II
基因别名: KIAA0619; P160ROCK; ROCK-I; ROCK-II; ROCK1; ROCK2
UniProt ID: (Human) Q13464, (Human) O75116
Entrez Gene ID: (Human) 6093, (Human) 9475
apical constriction
protein phosphorylation
cellular component disassembly involved in execution phase of apoptosis
smooth muscle contraction
leukocyte cell-cell adhesion
signal transduction
I-kappaB kinase/NF-kappaB signaling
Rho protein signal transduction
negative regulation of angiogenesis
membrane to membrane docking
actin cytoskeleton organization
regulation of cell adhesion
cortical actin cytoskeleton organization
bleb assembly
negative regulation of protein binding
regulation of actin cytoskeleton organization
negative regulation of myosin-light-chain-phosphatase activity
negative regulation of neuron apoptotic process
regulation of keratinocyte differentiation
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
leukocyte migration
leukocyte tethering or rolling
myoblast migration
regulation of stress fiber assembly
regulation of focal adhesion assembly
positive regulation of focal adhesion assembly
establishment of protein localization to plasma membrane
regulation of establishment of endothelial barrier
negative regulation of bicellular tight junction assembly
regulation of establishment of cell polarity
regulation of cell motility
cytokinesis
positive regulation of protein phosphorylation
positive regulation of endothelial cell migration
positive regulation of gene expression
positive regulation of centrosome duplication
regulation of circadian rhythm
rhythmic process
centrosome duplication
cellular response to testosterone stimulus
