Invitrogen

ROS1 Polyclonal Antibody

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ROS1 Antibody (PA5-110313) in WB

Western blot analysis of ROS1 in mouse brain. Samples were incubated with ROS1 Polyclonal antibody (Product # PA5-110313) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 3 min.

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产品信息

PA5-110313

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence within amino acids 1934-2232 of human ROS1 (NP_0029352?)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

3.02 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2855724

产品详细信息

Immunogen sequence: IENLPAFPRE KLTLRLLLGS GAFGEVYEGT AVDILGVGSG EIKVAVKTLK KGSTDQEKIE FLKEAHLMSK FNHPNILKQL GVCLLNEPQY IILELMEGGD LLTYLRKARM ATFYGPLLTL VDLVDLCVDI SKGCVYLERM HFIHRDLAAR NCLVSVKDYT SPRIVKIGDF GLARDIYKND YYRKRGEGLL PVRWMAPESL MDGIFTTQSD VWSFGILIWE ILTLGHQPYP AHSNLDVLNY VQTGGRLEPP RNCPDDLWNL MTQCWAQEPD QRPTFHRIQD QLQLFRNFFL NSIYKSRDE

靶标信息

ROS1 is a tyrosine kinase that functions as a growth or differentiation factor receptor. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: c-ros oncogene 1 , receptor tyrosine kinase; c-Ros receptor tyrosine kinase; c-ros-1; Proto-oncogene c-Ros; Proto-oncogene c-Ros-1; Proto-oncogene tyrosine-protein kinase ROS; Receptor tyrosine kinase c-ros oncogene 1; ROS proto-oncogene 1 , receptor tyrosine kinase; RP1-179P9.1; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1

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基因别名: c-ros; c-ros-1; MCF3; ROS; Ros-1; ROS1

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UniProt ID: (Human) P08922, (Mouse) Q78DX7

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Entrez Gene ID: (Human) 6098, (Mouse) 19886

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