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RPE65 Antibody (PA5-78414) in IHC (P)
RPE65 Polyclonal Antibody detects RPE65 protein at retinal pigment epithelium by immunohistochemical analysis. Sample: Paraffin-embedded mouse eye. Green: RPE65 stained by RPE65 Polyclonal Antibody (Product # PA5-78414) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, a neuronal marker, stained by beta Tubulin 3/ Tuj1 antibody [GT11710] diluted at 1:500. Blue: Fluoroshield with DAPI. Antigen Retrieval: Citrate ... View More
产品信息
PA5-78414
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human RPE65. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1.36 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2736536
产品详细信息
Positive Control: mouse eye
Predicted Reactivity: Rat (93%), Xenopus laevis (83%), Dog (97%), Chicken (89%), Bovine (98%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
RPE65 is a major protein of the retinal pigment epithelium (RPE). RPE65 is essential for the regeneration of rhodopsin in the visual cycle. Mutations in RPE65 are responsible for certain forms of autosomal recessive severe retinal dystrophy, including Leber Congenital Amaurosis (LCA). Loss of function results in a block in retinoid processing required for the synthesis of 11-cis retinal and the accumulation of retinyl esters in the RPE.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: All-trans-retinyl-palmitate hydrolase; BCO family, member 3; Lutein isomerase; Meso-zeaxanthin isomerase; modifier of retinal degeneration 1; p63; RBP-binding membrane protein; retinal pigment epithelium specific protein 65; retinal pigment epithelium, 65 kDa; Retinal pigment epithelium-specific 65 kDa protein; retinal pigment epithelium-specific protein 65kDa; Retinitis pigmentos; retinitis pigmentosa 20 (autosomal recessive); Retinoid isomerohydrolase; Retinol isomerase
基因别名: 65kDa; A930029L06Rik; BCO3; LCA2; Mord1; mRPE65; rd12; RP20; RPE65; sRPE65
UniProt ID: (Human) Q16518, (Mouse) Q91ZQ5
Entrez Gene ID: (Human) 6121, (Mouse) 19892
phosphatidylserine binding
retinal isomerase activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
phosphatidylcholine binding
metal ion binding
all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity
all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
cardiolipin binding
hydrolase activity
isomerase activity
oxygenase
retinoid metabolic process
retina homeostasis
neural retina development
vitamin A metabolic process
regulation of rhodopsin gene expression
visual perception
circadian rhythm
insulin receptor signaling pathway
retinol metabolic process
retinal metabolic process
detection of light stimulus involved in visual perception
oxidation-reduction process
retina morphogenesis in camera-type eye
cellular response to electrical stimulus
response to stimulus
retina development in camera-type eye
