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RTN1 Antibody (PA5-95761) in WB
Western blot analysis of RTN1 in extracts of Mouse lung. Samples were incubated with RTN1 Polyclonal antibody (Product # PA5-95761) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 5 min.
产品信息
PA5-95761
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human RTN1 (NP_0669591)
偶联物
形式
Liquid
浓度
1.53 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2807563
产品详细信息
Immunogen sequence: TGVAGVSSAM DHTFSTTSKD GEGSCYTSLI SDICYPPQED STYFTGILQK ENGHVTISES PEELGTPGPS LPDVPGIESR GLFSSDSGIE MTPAESTEVN KILADPLDQM KAEAYKYIDI TRPEEVKHQE QHHPELEDKD LDFKNKDTDI SIKPEGVREP DKPAPVEGKI IKDHLLEEST FAPYIDDLSE EQRRAPQITT PVKITLTEIE PSVETTTQEK TPEKQDICLK PSPDTVPTVT VSEPEDDSPG SITPPSSGTE P; Positive Samples: Mouse lung; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein
靶标信息
Reticulon-1 was formerly designated NSP for Neuroendocrine-Specific-Protein, because it is specifically expressed in neural and neuroendocrine tissues. The NSP-gene has been mapped by fluorescence in situ hybridization to human chromosome 14q21-q22. The NSP-gene encodes three overlapping proteins, i.e. reticulon-1A (NSP-A), reticulon-1B (NSP-B), and reticulon-1C (NSP-C). These proteins were found to be anchored to membranes of the endoplasmic reticulum through their common carboxy-terminal regions. Reticulon-1A is a protein with a molecular weight of approximately 135 kDa, which occurs in various isoforms presumably depending on the degree of phosphorylation of serine residues. In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is so far not found in human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 0710005K15Rik; 4930441F12Rik; MGC133250; MGC40985; Neuroendocrine-specific protein; R75279; Reticulon-1; RP23-450G14.1; Rtn1-a; Rtn1-b; Rtn1-c
基因别名: Nsp; Rtn1
UniProt ID: (Mouse) Q8K0T0
Entrez Gene ID: (Mouse) 104001
