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产品信息
MA1-06810
应用
建议稀释比
已发表文章
产品规格
种属反应
Hamster,
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
MON160
抗原
Partially purified bacterially expressed reticulon-1A (NSP-A) hybrid protein
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
purified
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2183568
产品详细信息
MA1-06810 detects reticulon-1A (NSP-A) in human, mouse, hamster, and rat samples.
MA1-06810 has sucessfully been used in Western blotting, FACS, ICC and immunohistochemistry procedures. By Western blot it detects a ~135 kDa band representing reticulon-1A.
The MA1-06810 immunogen is a partially purified bacterially expressed reticulon-1A (NSP-A) hybrid protein.
靶标信息
Reticulon-1 was formerly designated NSP for Neuroendocrine-Specific-Protein, because it is specifically expressed in neural and neuroendocrine tissues. The NSP-gene has been mapped by fluorescence in situ hybridization to human chromosome 14q21-q22. The NSP-gene encodes three overlapping proteins, i.e. reticulon-1A (NSP-A), reticulon-1B (NSP-B), and reticulon-1C (NSP-C). These proteins were found to be anchored to membranes of the endoplasmic reticulum through their common carboxy-terminal regions. Reticulon-1A is a protein with a molecular weight of approximately 135 kDa, which occurs in various isoforms presumably depending on the degree of phosphorylation of serine residues. In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is so far not found in human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 0710005K15Rik; 4930441F12Rik; MGC133250; MGC40985; Neuroendocrine-specific protein; R75279; reticulon 1; Reticulon-1; RP23-450G14.1; Rtn1-a; Rtn1-b; Rtn1-c; S-rex
基因别名: I79_024631; NSP; RTN1
UniProt ID: (Human) Q16799, (Rat) Q64548, (Mouse) Q8K0T0
Entrez Gene ID: (Chinese hamster) 100750648, (Human) 6252, (Rat) 116644, (Mouse) 104001
