NeoBiotechnologies

Rb1 (Tumor Suppressor Protein) Recombinant Rabbit Monoclonal Antibody (RB1, 2313R)

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Rb1 (Tumor Suppressor Protein) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Rb1 (Tumor Suppressor Protein) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Rb1 (Tumor Suppressor Protein) Antibody (5925-RBM3-P1ABX) in IHC (P)

Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human colon carcinoma using Rb1 (Tumor Suppressor Protein) Recombinant Monoclonal Antibody (Product # 5925-RBM3-P1ABX).

Rb1 (Tumor Suppressor Protein) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Rb1 (Tumor Suppressor Protein) Antibody in SDS-PAGE (SDS-PAGE)

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Rb1 (Tumor Suppressor Protein) Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human colon carcinoma using Rb1 (Tumor Suppressor Protein) Recombinant Monoclonal Antibody (Product # 5925-RBM3-P1ABX).

Rb1 (Tumor Suppressor Protein) Antibody in SDS-PAGE (SDS-PAGE) — SDS-PAGE Analyis Purified Rb1 (Tumor Suppressor Protein) Recombinant Monoclonal Antibody (Product # 5925-RBM3-P1ABX). Confirmation of Purity and Integrity of Antibody.

产品信息

5925-RBM3-P1ABX

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

RB1, 2313R

抗原

Recombinant human full-length Rb1 protein

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C or -80°C if preferred

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.

靶标信息

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Cleaved Rb; delta RB-p70; DRb-p70; exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; p105-Rb; P105RB; p110-RB1; Phospho-Retinoblastoma; pp105; pp110; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; Rb; Rb-p70; Retin; Retinoblastoma; retinoblastoma 1; retinoblastoma gene; retinoblastoma suspectibility protein; Retinoblastoma-associated protein

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基因别名: OSRC; p105-Rb; pp110; PPP1R130; pRb; RB; Rb-1; RB1

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UniProt ID: (Human) P06400, (Mouse) P13405

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Entrez Gene ID: (Human) 5925, (Mouse) 19645

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core promoter binding RNA polymerase II activating transcription factor binding DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding transcription factor binding kinase binding ubiquitin protein ligase binding identical protein binding androgen receptor binding phosphoprotein binding enzyme binding chromatin/chromatin-binding, or -regulatory protein

参与通路

cell cycle checkpoint G1/S transition of mitotic cell cycle regulation of transcription involved in G1/S transition of mitotic cell cycle chromatin remodeling transcription, DNA-templated negative regulation of protein kinase activity cell cycle arrest negative regulation of transcription from RNA polymerase II promoter during mitosis mitotic cell cycle checkpoint Ras protein signal transduction regulation of mitotic cell cycle negative regulation of gene expression viral process covalent chromatin modification androgen receptor signaling pathway sister chromatid biorientation neuron projection development maintenance of mitotic sister chromatid cohesion glial cell apoptotic process skeletal muscle cell differentiation neuron maturation enucleate erythrocyte differentiation negative regulation of sequence-specific DNA binding transcription factor activity regulation of lipid kinase activity myoblast differentiation positive regulation of macrophage differentiation positive regulation of mitotic metaphase/anaphase transition negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter digestive tract development cell morphogenesis involved in neuron differentiation negative regulation of epithelial cell proliferation striated muscle cell differentiation cell division neuron apoptotic process protein localization to chromosome, centromeric region cellular response to xenobiotic stimulus regulation of cohesin loading negative regulation of transcription involved in G1/S transition of mitotic cell cycle regulation of centromere complex assembly hepatocyte apoptotic process negative regulation of G1/S transition of mitotic cell cycle positive regulation of transcription regulatory region DNA binding negative regulation of transcription from RNA polymerase II promoter regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cell cycle negative regulation of cell proliferation chromatin modification neuron differentiation negative regulation of cell cycle negative regulation of mitotic cell cycle regulation of cell cycle negative regulation of hepatocyte apoptotic process