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产品信息
MA5-54681
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Alpaca
/ VHH
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
SAA1319
抗原
Recombinant Human RHOB.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Metal-chelate chromatography
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
靶标信息
Rho-related GTP-binding protein (RhoB) mediates apoptosis in neoplastically transformed cells after DNA damage. While not essential for development, it does affect cell adhesion and growth factor signaling in transformed cells. RhoB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a tumor supressor - deletion of RhoB causes tumor formation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Aplysia RAS-related homolog 6; h6; oncogene RHO H6; ras homolog gene family, member B; Rho; Rho cDNA clone 6; Rho-related GTP-binding protein RhoB
基因别名: ARH6; ARHB; MST081; MSTP081; RHOB; RHOH6
UniProt ID: (Human) P62745
Entrez Gene ID: (Human) 388
cytokinesis
angiogenesis
intracellular protein transport
apoptotic process
cell adhesion
Rho protein signal transduction
endosome to lysosome transport
positive regulation of endothelial cell migration
cell differentiation
platelet activation
regulation of cell migration
negative regulation of cell migration
positive regulation of apoptotic process
positive regulation of angiogenesis
negative regulation of cell cycle
regulation of small GTPase mediated signal transduction
endothelial tube morphogenesis
cellular response to hydrogen peroxide
cellular response to ionizing radiation
