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产品信息
PA5-20610
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 14 amino acid peptide near the carboxy terminus of the human S1P1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11155829
产品详细信息
A suggested positive control is mouse thymus tissue lysate.
PA5-20610 can be used with blocking peptide PEP-0730.
靶标信息
S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins. S1P1 signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. It plays an important role in cell migration via its role in the reorganization of the actin cytoskeleton and formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. S1P1 is required for normal chemotaxis toward sphingosine 1-phosphate, normal embryonic heart development, and normal cardiac morphogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD antigen CD363; CD363; CD363 antigen; EDG1 (Edg1); Endothelial differentiation G-protein coupled receptor 1; endothelial differentiation sphingolipid G-protein-coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; Lysophospholipid receptor B1; S1P receptor 1; S1P receptor Edg-1; S1P1; Sphingosine 1-phosphate receptor 1; Sphingosine 1-phosphate receptor Edg-1; sphingosine 1-phosphate receptor EDG1
基因别名: AI849002; CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1; Lpb1; S1p; S1P1; S1PR1
UniProt ID: (Human) P21453, (Rat) P48303, (Mouse) O08530
Entrez Gene ID: (Human) 1901, (Rat) 29733, (Mouse) 13609
angiogenesis
blood vessel maturation
cardiac muscle tissue growth involved in heart morphogenesis
sphingosine-1-phosphate signaling pathway
chemotaxis
cell adhesion
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
brain development
cell migration
transmission of nerve impulse
lamellipodium assembly
regulation of cell adhesion
neuron differentiation
positive regulation of cell migration
regulation of bone mineralization
actin cytoskeleton reorganization
positive regulation of GTPase activity
regulation of bone resorption
endothelial cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
positive regulation of positive chemotaxis
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
negative regulation of stress fiber assembly
heart trabecula morphogenesis
T cell migration
positive regulation of cell proliferation
signal transduction
