Invitrogen

SAMHD1 Recombinant Rabbit Monoclonal Antibody (JU56-04)

SAMHD1 Antibody in Immunocytochemistry (ICC/IF)

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SAMHD1 Antibody (MA5-32810) in ICC/IF

Immunocytochemical analysis of SAMHD1 in HUVEC cells using a SAMHD1 Monoclonal antibody (Product # MA5-32810) as seen in green. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

SAMHD1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

SAMHD1 Antibody in Flow Cytometry (Flow)

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产品信息

MA5-32810

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:100-1:500

流式细胞分析 (Flow)

1:50-1:100

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

JU56-04

抗原

Synthetic peptide within Human SAMHD1 aa 577-626

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2810086

产品详细信息

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Biodistribution of a Mitochondrial Metabolic Tracer, [¹⁸F]F-AraG, in Healthy Volunteers.

Molecular imaging

Levi J,Duan H,Yaghoubi S,Packiasamy J,Huynh L,Lam T,Shaikh F,Behera D,Song H,Blecha J,Jivan S,Seo Y,VanBrocklin HF

MA5-32810 was used in Flow cytometry/Cell sorting to show that [18F]F-AraG's connection with mitochondrial biogenesis and favorable biodistribution characteristics make it an attractive tracer with a variety of potential applications.

Fri Sep 09 00:00:00 EDT 2022

生物信息学

蛋白别名: DCIP; Dendritic cell-derived IFNG-induced protein; Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; dNTPase; hSAMHD1; Monocyte protein 5; MOP-5; RP1-132F21.1; SAM domain and HD domain 1; SAM domain and HD domain-containing protein 1

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基因别名: CHBL2; DCIP; HDDC1; MOP-5; MOP5; SAMHD1; SBBI88

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UniProt ID: (Human) Q9Y3Z3

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Entrez Gene ID: (Human) 25939

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功能

nucleic acid binding RNA binding protein binding zinc ion binding dGTPase activity dGTP binding hydrolase

参与通路

dGTP catabolic process immune response regulation of innate immune response dATP catabolic process protein homotetramerization defense response to virus type I interferon signaling pathway