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Immunogen sequence: ARFKDLNLAG TAEVGLAGYF MDHTVAFRDL PVRMVCSSTC YRAETNTGQE PRGLYRVHHF TKVEMFGVTG PGLEQSSQLL EEFLSLQMEI LTELGLHFRV LDMPTQELGL PAYRKFDIEA WMPGRGRFGE VTSASNCTDF QSRRLHIMFQ TEAGELQFAH TVNATACAVP RLLIALLESN QQKDGSVLVP PALQSYLGTD RITAPTHVPL QYIGPNQPRK PGLPGQPAVS
This gene encodes the mitochondrial seryl-tRNA synthetase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: EC 6.1.1.11; mitochondrial seryl-tRNA synthetase; serine tRNA ligase 2, mitochondrial; Serine--tRNA ligase, mitochondrial; serine-tRNA ligase; serine-tRNA ligase, mitochondrial; SerRS; SerRSmt; Seryl-tRNA synthetase; seryl-tRNA synthetase, mitochondrial; Seryl-tRNA(Ser/Sec) synthetase
基因别名: 2410015F05Rik; D7Ertd353e; mtSerRS; SARS; SARS2; SARSM; SerRS; SerRSmt; SERS; SYS
UniProt ID: (Human) Q9NP81, (Mouse) Q9JJL8
Entrez Gene ID: (Human) 54938, (Mouse) 71984