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产品信息
PA5-98928
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Protein salvador homolog 1 protein (1-210AA)
偶联物
形式
Liquid
浓度
0.31 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2813541
靶标信息
Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. It also plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, Sav1 activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
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生物信息学
蛋白别名: 1700040G09Rik; 45 kDa WW domain protein; hWW45; mWW45; Protein salvador homolog 1; salvador homolog 1; WW domain-containing adaptor 45; WW domain-containing protein 3; WW domain-containing protein 4
基因别名: 1700040G09Rik; Salv; SAV; SAV1; WW45; Wwp3; WWP4
UniProt ID: (Human) Q9H4B6, (Mouse) Q8VEB2
Entrez Gene ID: (Human) 60485, (Mouse) 64010
hair follicle development
signal transduction
keratinocyte differentiation
hippo signaling
positive regulation of apoptotic process
positive regulation of fat cell differentiation
regulation of organ growth
negative regulation of epithelial cell proliferation
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
negative regulation of cardiac muscle cell proliferation
ventricular septum morphogenesis
lung epithelial cell differentiation
intestinal epithelial cell differentiation
regulation of stem cell population maintenance
