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Immunogen sequence: EGLQHLGPFG NIPNIVAELT GDNIPKDFSE DQGYPDPPNP CPVGKTADDG CLENTPDTAE FSREFQLHQH LFDPEHDYPG LGKWNKKLLY EKMKGGERRK RRSVNPYLQG QRLDNVVAKK SV
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Neuroendocrine protein 7B2; P SGNE1; Pituitary polypeptide; prohormone convertase chaperone; Secretogranin V; secretogranin V (7B2 protein); Secretogranin-5; Secretory granule endocrine protein I; secretory granule, neuroendocrine protein 1 (7B2 protein)
基因别名: 7B2; P7B2; SCG5; SGNE1; SgV
UniProt ID: (Human) P05408
Entrez Gene ID: (Human) 6447
分子生物学功能:
chaperone