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SCO1 Antibody (PA5-54452) in IHC
Immunohistochemical staining of SCO1 in human liver using a SCO1 Polyclonal Antibody (Product # PA5-54452) shows moderate cytoplasmic positivity in hepatocytes.
产品信息
PA5-54452
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2647020
产品详细信息
Immunogen sequence: TREEVDQVAR AYRVYYSPGP KDEDEDYIVD HTIIMYLIGP DGEFLDYFGQ NKRKGEIAAS IATHMRPYR
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 86%.
靶标信息
Synthesis of cytochrome c oxidase 1 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO1 and SCO2 are dependent on copper ion binding. Mutations in either gene can lead to cytochrome c oxidase respiratory chain defects, with a missense mutation in human SCO1 (P174L) associated with a fatal neonatal hepatopathy when the second allele is also non-functional, suggesting the pathology is due to loss of function. It has been suggested that this mutation alters the SCO1 affinity for the copper (I) ion, thus impairing the efficiency of copper transfer to the cytochrome c oxidase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Protein SCO1 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 1
基因别名: SCO1; SCOD1
UniProt ID: (Human) O75880
Entrez Gene ID: (Human) 6341
