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产品信息
PA5-20990
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 14 amino acid peptide near the center of human SCUBE1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11152634
产品详细信息
A suggested positive control is Daudi cell lysate.
PA5-20990 can be used with blocking peptide PEP-1104.
靶标信息
SCUBE1 is an EGF-related protein with a CUB (C1s-like) domain that is expressed primarily in the developing gonad, nervous system, somites, surface ectoderm and limb buds. The N-terminal EGF-like repeats of SCUBE1 participate in the formation of adhesions in a Ca2+-dependent fashion. In contrast, the C-terminal cysteine-rich motifs and CUB domain can directly bind and antagonize bone morphogenic protein activity; genetic ablation of this region resulted in brain malformation in mice embryos, suggesting SCUBE1 plays a role in brain morphogenesis. SCUBE1 has also been implicated in early craniofacial development in mice.
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生物信息学
蛋白别名: signal peptide; Signal peptide, CUB and EGF-like domain-containing protein 1; signal peptide, CUB domain, EGF-like 1; signal peptide-CUB domain-EGF-related 1
基因别名: SCUBE1
UniProt ID: (Human) Q8IWY4
Entrez Gene ID: (Human) 80274
