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A suggested positive control is A-20 cell lysate.
PA5-34420 can be used with blocking peptide PEP-1462.
SELK is a selenoprotein, containing a selenocysteine residue at its active site. SELK is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. SELK can bind to proteins such as the ER-associated degradation (ERAD) components p97 ATPase, Derlin-1 and -2, and SelS as well as proteins in the oligosaccharyltransferase complex, suggesting that SELK may be involved in the Derlin-dependent ERAD of glycosylated misfolded proteins. SELK is also thought to be important in Ca2+ flux in immune cells, and is cleaved by m-calpain in resting macrophages. When these macrophages are activated through different Toll-like receptors, this cleavage is inhibited.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: heat shock protein; heat shock protein, 30 kDa; Selenoprotein K; SelK
基因别名: 1110001C03Rik; AA673253; Hsp30; HSPC030; HSPC297; SELENOK; SELK
UniProt ID: (Human) Q9Y6D0, (Mouse) Q9JLJ1, (Rat) P59798
Entrez Gene ID: (Human) 58515, (Mouse) 80795, (Rat) 290549