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Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7.
Predicted reactivity: Mouse (97%), Xenopus laevis (82%), Rhesus Monkey (80%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
SUMO (small ubiquitin-related modifier), a member of the ubiquitin-like protein family, regulates diverse cellular functions of a variety of target proteins including transcription, DNA repair, nucleocytoplasmic trafficking and chromosome segregation. SUMO precursor proteins undergo cleavage of the residues after the "GG" region by SUMO-specific proteases in maturation. This cleavage of the precursor is a prerequisite for subsequent sumoylation. The sentrin-specific (or SUMO-specific) protease (SENP) proteins belong to the peptidase C48 family and include SENP1-3 and SENP5-8. SENP1, SENP2 and SENP3 degrade UBL1 and SMT3H2 conjugates and subsequently release the monomers from sumoylated substrates.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DKFZp564O1016; FLJ42398; MGC27076; Sentrin-specific protease 5; Sentrin/SUMO-specific protease SENP5; SUMO1/sentrin specific protease 5
基因别名: FKSG45; SENP5
UniProt ID: (Human) Q96HI0
Entrez Gene ID: (Human) 205564
分子生物学功能: protease