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产品信息
PA5-86763
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to residues in Human ATP2A2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2803523
产品详细信息
Purity is > 95% by SDS-PAGE.
靶标信息
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATPase Ca++ transporting cardiac muscle slow twitch 2; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; ATPase, Ca++ transporting, slow twitch 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; cardiac Ca2+ ATPase; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2; sarco/endoplasmic reticulum Ca2+-ATPase 2; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA; SERCA ATPase; SERCA2; SR Ca(2+)-ATPase 2
基因别名: 9530097L16Rik; ATP2A2; ATP2B; D5Wsu150e; DAR; DD; mKIAA4195; SERCA2; Serca2a; SERCA2B; SercaII
UniProt ID: (Human) P16615, (Mouse) O55143, (Rat) P11507
Entrez Gene ID: (Human) 488, (Mouse) 11938, (Rat) 29693
calcium-transporting ATPase activity
calcium ion binding
protein binding
ATP binding
protein C-terminus binding
enzyme binding
lutropin-choriogonadotropic hormone receptor binding
S100 protein binding
calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential
nucleotide binding
hydrolase activity
metal ion binding
primary active transporter
regulation of the force of heart contraction
ER-nucleus signaling pathway
organelle organization
cell adhesion
epidermis development
positive regulation of heart rate
regulation of cardiac muscle contraction by calcium ion signaling
transition between fast and slow fiber
endoplasmic reticulum calcium ion homeostasis
positive regulation of endoplasmic reticulum calcium ion concentration
T-tubule organization
ion transmembrane transport
cellular response to oxidative stress
response to endoplasmic reticulum stress
response to peptide hormone
negative regulation of heart contraction
relaxation of cardiac muscle
sarcoplasmic reticulum calcium ion transport
calcium ion transmembrane transport
regulation of cardiac muscle cell membrane potential
regulation of cardiac muscle cell action potential involved in regulation of contraction
regulation of calcium ion-dependent exocytosis of neurotransmitter
calcium ion transport from cytosol to endoplasmic reticulum
regulation of cardiac conduction
calcium ion import into sarcoplasmic reticulum
transport
ion transport
calcium ion transport
cellular calcium ion homeostasis
regulation of muscle contraction
metabolic process
