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Immunogen sequence: FALNLLKTLG KDNSKNVFFS PMSMSCALAM VYMGAKGNTA AQMAQILSFN KSGGGGDIHQ GFQSLLTEVN KTGTQYLLRM ANRLFGEKSC DFLSSFRDSC QKFYQAEMEE LDFISAVEKS RKHINTWVAE KTEGKIAELL SPGSV
The protein encoded by this gene is a member of the serpin superfamily, and ovalbumin-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CAP; Cytoplasmic antiproteinase; DKFZp686I04222; MGC111370; Peptidase inhibitor 6; PI-6; Placental thrombin inhibitor; protease inhibitor 6 (placental thrombin inhibitor); RP1-90J20.6; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6; Serpin B6; serpin peptidase inhibitor, clade B (ovalbumin), member 6
基因别名: CAP; DFNB91; MSTP057; PI-6; PI6; PTI; SERPINB6; SPI3
UniProt ID: (Human) P35237
Entrez Gene ID: (Human) 5269